Development of a Novel Nanocomposite Coating for Dental and Orthopedic Implants

IUT graduate student, Mehdi Mehdikhani Nahrkhalaji, successfully did his PhD dissertation on the preparation, characterization, and evaluation of biodegradable and antibacterial nanocomposite coating for dental and orthopedic implants.

Mr. Mehdikhani suggested that in order to select the most suitable bioactive glass, three types of bioactive glass nanoparticles with different compositions (58S, 63S, and 72S) were synthesized via sol-gel technique. Then, the antibacterial activity against four aerobic bacteria, the four major nosocomoal pathogens, cytotoxicity of the bioactive glass nanoparticles, together with the subcutaneous connective tissue reactions to the bioactive glass nanoparticles were evaluated.
Mr. Mehdikhani added that the results of the study showed that 58S and 63S compositions possess antibacterial feature without cytotoxicity. These nanoparticles are also well-tolerated by the subcutaneous connective tissue. Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), XRD, and Atomic Force Microscopy (AFM) were used to characterize the three types of nanocomposite coatings (PLGA/HA/BG, PLGA/HA, and PLGA/BG), the coatings prepared by the same researcher.
The first graduated PhD student in Biomaterials at IUT Department of Materials Engineering indicated that the bioactivity analysis of the nanocomposite coatings was done in simulated human body solution which lead to the formation of apatite on the coatings.
Mehdikhani believes that degradable and antibacterial nanocomposite coating with the capability of inducing the stem cells proliferation with suitable adhesion to the implant can be used as a good candidate on the dental and orthopeadic implants in order to enhance the rate of bone tissue repair in an antibacterial environment.
It is worth mentioning that this IUT top graduate was able to carry out his research under the supervision of Professor Fathi at IUT Department of Materials Engineering and Dr. Mortazavi at the University of Isfahan.

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